منابع مشابه
Cholesterol oxides accumulate in human cataracts.
Human lens membranes contain the highest cholesterol content of any known biological membrane. Although cholesterol is prone to oxidation, the presence of its oxidation products in human cataract has not been shown before. This study was designed to investigate the presence of cholesterol oxides in human cataractous lenses. Human clear lenses (n = 48) were obtained from Coimbra University Hospi...
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Cholesterol prevents Alzheimer’s lood vessels work best when they are clear of cholesterol. But neurons need cholesterol to maintain top form, according to Abad-Rodriguez et al. (page 953). With too little of this membrane lipid, neurons produce more of the Alzheimer’sassociated amyloid peptide (A ). The results are a warning that the effects of cholesterol-lowering drugs may need to be confine...
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Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications. APP cleavage is tightly regulated by cholesterol and APP fragments regulate lipid homeostasis. Here, we investigated whether up or down regulation of full-length APP expression affected neuronal lipid metabolism. Expression of APP decrease...
متن کاملSqualene as a precursor of cholesterol in liver.
Many compounds have been implicated as capable of serving as precursors for cholesterol, and of these the most intriguing is undoubtedly squalene. In 1926, and again in 1937, Channon (1, 2) reported that the .feeding of squalene to rats resulted in an increased cholesterol content of the liver. These observations led Srere (3), in 1949, in this laboratory, to study the conversion of acetate-Cl4...
متن کاملGlutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.
Treatment of newborn rats and mice with buthionine sulfoximine, an inhibitor of glutathione synthesis, leads to development of cataracts, which are not prevented by treatment with glutathione, but they are prevented by treatment with glutathione monoester. Cataracts are associated with glutathione deficiency in the lens epithelium, which undergoes severe degeneration. The findings indicate that...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4721